Comment on “polygenic scores: A public health hazard?”

Polygenic hazard scores in preclinical Alzheimer disease.

Identifying asymptomatic older individuals at elevated risk for developing Alzheimer disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive decline, even after controlling for APOE ɛ4 carrier status. Older individuals in the highest PHS percent...

Predicting Alzheimer's disease: a polygenic hazard score.

the genetic factors that influence the development of alzheimer’s disease (ad) have been the subject of large international collaborative studies in recent years involving many thousands of patients and controls. genome wide association screens (gWas) have produced large datasets which include not only genetic linkage information but also clinical material such as age of disease onset and, in s...

Acyclovir as a public health hazard.

Health Consultation Public Comment Version

Polygenic Selection, Polygenic Scores, Spatial Autocorrelation and Correlated Allele Frequencies. Can We Model Polygenic Selection on Intellectual Abilities?

The majority of polygenic selection signal of educational attainment GWAS hits is confined to a handful of SNPs within genomic regions replicated across GWAS publications. A polygenic score comprising 9 SNPs predicts population IQ (r=0.9), outperforming 99.9% of the polygenic scores obtained from sets of random SNPs. Its predictive power remains unaffected after controlling for spatial autocorr...